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It is often used for weight-loss purposes, as it has been suggested to improve Anxiety medication weight loss side effect tolerance, reduce LDL plasma levels, and contribute to global inhibition of body weight gain [ 1925 ].

There is evidence of ginseng modulatory activity on the noradrenergic, dopaminergic, serotoninergic, cholinergic, and endorphin systems [ 26 — 28 ], and there have been several reports of psychiatric symptoms associated with the use of ginseng both in healthy people and in patients previously affected by psychiatric disorders reviewed below. In the World Health Organization WHO Collaborating Centre for International Drug Monitoring Database and UK Medicines Control Agency reports of adverse events, ginseng monopreparations have been associated with cases of insomnia, nervousness, manic reaction, amnesia, somnolence, anorexia, anxiety, emotional lability, hallucination, sleep disorder, confusion, depression, and abnormal thinking [ 24 ].

Some studies have also reported associations in the exacerbation or worsening of psychiatric symptoms with ginseng use in patients affected by psychiatric disorders.

Two case reports by Gonzalez-Seijo et al. Gonzalez-Seijo et https://vegetale.galbine.top/articulo12136-pastillas-naturales-para-adelgazar-elite-motors.php. It is not known, however, if ginseng per se may have induced the manic episode or, rather, the manic episode was precipitated by amitriptyline or lithium withdrawal [ 32 ].

A third report described that five inpatients with schizophrenia became irritable, uncooperative, Anxiety medication weight loss side effect overactive with disturbed sleep after smoking ginseng-containing cigarettes and that, after cessation of smoking these cigarettes, these behavioural symptoms improved [ 34 ]. Ephedra sinica ma-huang is an evergreen shrub native to Central Asia, whose dried parts have been used for thousands of years in the traditional Anxiety medication weight loss side effect medicine for the treatment of various respiratory conditions [ 35 ].

Its main biologically active component is the alkaloid ephedrine, a Anxiety medication weight loss side effect agent [ 36 ]. The chemical structure of ephedrine is very similar to that of amphetamine; in fact, amphetamines have been originally synthesized as a substitute for ephedrine [ 36 ]. Ina Danish physician first noted unintentional weight loss in a patient taking ephedrine-containing pills for asthma Anxiety medication weight loss side effect 37 ].

Subsequently, ma-huang became one of the most commonly used herbs for weight loss [ 38 ]. A Adelgazar 40 kilos reported that ma-huang promoted modest short-term weight loss approximately 0. This effect is said to be mainly due to a sympathomimetic stimulation of thermogenesis in skeletal muscles [ 3740 ]. Ephedrine can rapidly pass through the blood-brain barrier [ 35 ] and can stimulate short-term release of dopamine and norepinephrine, as well as long-term depletion of monoamine [ 41 ].

Anxiety medication weight loss side effect use has been associated with several psychiatric adverse effects reviewed below. A meta-analysis of 50 trials on the use of ma-huang in the treatment of obesity yielded estimates of 2.

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In a review of 1, previously unpublished Food and Drug Administration FDA reports of adverse events concerning ma-huang, the use of the herb was associated with 57 serious psychiatric episodes [ 41 ]. Thirty-two Other common adverse events not mutually exclusive were severe depression Most patients Both patients reportedly used ephedrine to treat respiratory diseases and had no previous mental illnesses [ 42 ]. Additional cases of ephedrine-induced psychosis have more recently Adelgazar 15 kilos described [ 43 — 46 ].

In relation to mood disorders, several published case reports reported the association between ma-huang use and manic-like symptoms, such as psychomotor agitation, pressured speech, flight of ideas, suicidal ideation, irritability, aggressive and disorganized behavior, and reduced need for sleep [ 45 — 50 ].

Manic-like symptoms occurred both in patients with no previous psychiatric illness and in patients with a family history of bipolar disorder. These manic-like symptoms occurred when ma-huang was being assumed at the manufacturer recommended dosages, at doses exceeding the recommended amounts, or after dose escalation the exact dosages were not reported [ 45 — 50 ].

Following acute manic episodes, symptom remission was typically achieved with or without pharmacotherapy [ Anxiety medication weight loss side effect — 50 ], although one patient reportedly developed long-lasting residual disturbances such as boundary control and obtrusive, loud speech [ 47 ]. Two case reports also detected the association between ma-huang use and depressed mood [ 4445 ], with depressive symptoms occurring after 1 year of use [ 44 ] or after the first use [ 45 ] of the herb.

Anxiety medication weight loss side effect case report described Anxiety medication weight loss side effect woman with Anxiety medication weight loss side effect obsessive-compulsive disorder who was effectively treated with fluvoxamine and Eye Movement Desensitization and Reprocessing EMDR treatments but relapsed following the ingestion of a single capsule of an herbal product containing ma-huang used to facilitate weight loss [ 51 ].

An additional relevant adverse psychiatric effect possibly related to ma-huang use is the onset of ephedrine addiction. Miller and Waite reported the case of a year-old male with no psychiatric comorbidity whose use of a dietary supplement containing ma-huang progressed to substance abuse and quite possibly substance dependence [ 52 ]. He progressively escalated the assumed dose to more than four times the recommended amount one capsule, two times per dayAnxiety medication weight loss side effect symptoms of tolerance and withdrawal [ 52 ].

In a case series of seven patients with amphetamine-like abuse or dependence, two showed ephedrine abuse and three ephedrine dependence according to the DSM-IV diagnostic criteria [ 53 ]. The FDA reports of adverse events found five patients 8. Paullinia cupana guarana is a plant native to the Amazon region and is especially common in Brazil [ 55 ].

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Guarana seeds contain a wide number of stimulant and psychoactive substances, including twice the amount of caffeine present in coffee beans and other xanthine alkaloids such as theobromine and theophylline [ 5556 ].

The plant is commonly used in soft drinks and energy drinks but its stimulant properties have made it a frequent ingredient in weight-loss compounds, with some evidence supporting its weight-loss effectiveness [ 47 — 49 ]. Due to the high caffeine content of its seeds, Anxiety medication weight loss side effect intake of guarana may cause symptoms of caffeine intoxication e.

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The World Anxiety medication weight loss side effect Organization-Adverse Drug Reactions WHO-ADR database reported guarana to be associated with cases of personality disorder, manic reaction, insomnia, somnolence, asthenia, fatigue, anxiety, and impaired concentration [ 2360 ]. Galduróz and Carlini [ 61 ] and Boozer et al. Pausinystalia yohimbe is a plant native to Central Africa [ 63 ].

Anxiety medication weight loss side effect

The association between yohimbine, an alkaloid derived from the bark of the plant, and weight loss has been consistently reported [ 2363 — 66 ]. For example, Kucio et Anxiety medication weight loss side effect. Yohimbine is Anxiety medication weight loss side effect alpha2-adrenoceptor antagonist that produces sympathetic activation by increasing noradrenaline release and the firing rate of neurons located in noradrenergic nuclei of the central nervous system CNS [ 6768 ].

Consistently, increases in anxiety symptoms are the most commonly reported adverse psychiatric effects associated with yohimbine, both in healthy people [ 6970 ] and in psychiatric patients especially in those with preexistent anxiety disorders [ 71 — 76 ].

In healthy individuals, an intravenous dose of yohimbine 0.

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A significant decrease of cerebral blood flow, especially in the cortical regions, following yohimbine administration has also been observed [ 69 ]. Charney et al. Anxiety medication weight loss side effect, Gurguis et al. The increase of anxiety symptoms after intravenous dose of yohimbine 0.

In addition to anxiety, yohimbine has also been associated with other adverse psychiatric effects. Yohimbine has been reported to induce addictive drug seeking behaviour [ 77 ], objective and subjective withdrawal, and elevated craving in heroin-dependent patients [ 78 Anxiety medication weight loss side effect.

Scherr et al. It is reported that, compared to placebo, oral administration of yohimbine 0. Finally, Price et al. Herb-drug interactions have become an important issue in drug safety and clinical practice, possibly resulting in drug toxicities, reduced pharmacological effects, and adverse drug reactions.

In this section we review the available evidence of interactions between HWLPs and psychiatric medications. Two case reports suggest an interaction between ginseng and phenelzine [ 84 — 86 ].

A year-old woman described symptoms of headache and tremulousness when ginseng was added to her phenelzine therapy; three years later, whilst still taking phenelzine, she experienced similar symptoms upon Adelgazar 72 kilos ginseng capsules [ 8586 ].

When the ginseng preparation was discontinued, she no longer experienced Anxiety medication weight loss side effect therapeutic benefit of the phenelzine [ 84 ]. An interaction between ginseng, vitamin B complex, and sertraline resulting in a reduction of therapeutic response has also been reported [ 24 ].

Anxiety medication weight loss side effect

Ginseng contains a mixture of saponin glycosides called ginsenosides. It has been found that ginsenosides inhibit cyclic AMP phosphodiesterase [ 87 ]; this may account partly for ginseng interaction with monoamine oxidase inhibitors MAOIs such as phenelzine, although an exact delineation of the mechanism would require further study.

As written above, the predominant active component of ma-huang, that is, ephedrine, is a sympathomimetic agent with a chemical structure very similar to that of amphetamine [ 36 ]. It acts directly and indirectly at alpha- and beta-adrenergic receptors, potentially causing increased blood pressure Dietas rapidas heart rate, relaxation of bronchial and gastrointestinal smooth muscle, CNS stimulation, and mydriasis [ 88 ].

When ma-huang is administered in combination with MAOIs, its sympathomimetic activity can reportedly increase the risk of Anxiety medication weight loss side effect crisis [ 89 ]. However, it is also possible that stopping the phenelzine suddenly contributed to inducing the side effects. Guarana extracts have high content of caffeine [ 5556 ], which is metabolized by CYP1A2 a protein of the cytochrome P family of isoenzymes Anxiety medication weight loss side effect for the biotransformation of several drugs [ 5890 ].

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When used concomitantly, caffeine and certain psychiatric medications e. One study has also reported that abruptly ceasing the daily consumption of caffeine may result in a significant increase in lithium blood levels [ Anxiety medication weight loss side effect ]. However, no studies have reported interactions between guarana and psychiatric medications so far. Pharmacodynamic and pharmacokinetic interactions between yohimbine and certain tricyclic antidepressants i.

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